Very Low Blood Count With Swollen Ankles And Weight Loss Is Osteoarthritis Part of Metabolic Syndrome?

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Is Osteoarthritis Part of Metabolic Syndrome?

Osteoarthritis is the breakdown of cartilage, a spongy protein that covers the ends of bones in a joint. Normal cartilage aids in diving by acting as a cushion for the ends of bones. Cartilage is the fluid in the joint that allows for smooth movement. As osteoarthritis progresses, the space between the bones narrows, the cartilage wears away, and the underlying bone is exposed. This causes joint pain and limited range of motion. Scars can grow around the joint, limiting movement and causing more pain. Inflammation plays a small role in osteoarthritis.

Osteoarthritis has many causes, the most common of which is aging. As we age, cartilage fluidity increases and protein content decreases. As water rises, it softens, slows down, and loses its mechanical properties. As the protein content decreases, the cartilage wears down and wears away.

Other causes of osteoarthritis include bone loss. In the foot, the main reason is the failure of the foot mechanics. If the foot is out of alignment and not working properly, it can put abnormal stress on the joints of the feet, ankles, knees, hips and back. Pain is a common cause of arthritis. Chronic injury can disrupt the joint structures, misalign the joint, or weaken the surrounding structures, resulting in joint instability and osteoarthritis. Other factors, such as infection, medication (such as steroids) and genetics can play a role in the development of arthritis.

Obesity is a cause of arthritis. The exact mechanism by which weight affects osteoarthritis is unclear. While excess weight is placed on the flat surfaces of the cartilage more quickly, obesity is also associated with osteoarthritis of the wrist, suggesting a more systemic cause. Obesity increases the risk of developing metabolic syndrome. Metabolic syndrome is a disease characterized by a combination of risk factors associated with coronary heart disease, stroke and type 2 diabetes. Risk factors include high blood pressure, high obesity (fat around the waist), abnormal cholesterol levels (such as high triglyceride levels and low HDL levels) and insulin resistance (equivalent to high blood sugar). The underlying concepts of metabolic syndrome are tied to the body’s metabolism, the ability to resist insulin. Insulin resistance is the inability to properly use insulin, a hormone that transports sugar from the blood to the cells. The result is high blood sugar. Insulin resistance is linked to obesity and inactivity.

In a recent study in the journal Skeletal Radiology, the thickness of the popliteal wall was assessed in people with osteoarthritis. Forty-two patients were diagnosed with osteoarthritis in multiple joints compared to 27 patients without osteoarthritis (the control group). An MRI of the knee was used to assess the thickness of the popliteal wall. The osteoarthritis group had thicker vessel walls than the control group, even when the researchers made adjustments for gender, weight and age. Because the thickening of the walls of the vessels is associated with high blood pressure and the disease of the lungs and throat, the authors say that osteoarthritis is another part of the metabolic syndrome.

One theory to explain the link between osteoarthritis and metabolic syndrome is based on white blood cells, immune cells, increasing in areas where fat accumulates, especially in the side of the stomach (you big). As white blood cells increase, they become involved in widespread inflammation in the body, resulting in a pro-inflammatory state (indicated by high blood levels of C-reactive protein) and the formation of inhibitory substances (specific cytokines) that cause a chain reaction. causing damage to the card. The combination of insulin resistance and a pro-inflammatory state may affect the repair processes of the pancreas.

Osteoarthritis may not be an inevitable outcome for those with metabolic syndrome.

Kornaat PR et al. Positive association between increased wall thickness of the popliteal artery and generalized osteoarthritis: is OA part of an autoimmune disease? Bone Radiology. 2009 July 3.
Rojas-Rodríguez J, et al. The relationship between metabolic syndrome and impaired energy use in the pathogenesis of osteoarthritis-induced. Med Concepts. 2007;69(4):860-8.
Cicuttini FM, Baker JR, Spector TD: The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J. Rheumatol. 1996; 23:1221-1226.
Felson DT: Weight and osteoarthritis. J. Rheumatol. 1995;43:7-9.
Armstrong CG, Mow VC. Differences in the Intrinsic Mechanisms of Human Arthritis Development with Age, Depression, and Water Content. JBJS. 1982; 64:88-94.

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