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Hydroxycitric Acid, Bad Science and Liver Failure
Hydroxycitric Acid (HCA) is the cause of liver damage and liver failure in users of Hydroxycut products. Iovate Health Sciences USA Inc, has withdrawn 14 Hydroxycut products from the market after the FDA announced on May 1, 2009 that it had received 23 user reports of adverse effects. liver, some are so severe that a liver transplant is needed. A 19-year-old boy who used Hydroxycut died of liver failure.
Fourteen products that are now taken from Hydroxycut:
- Fast Delivery Caplets Always
- Caffeine Free Fast Delivery Caplets
- Hardcore Liquid Caplets
- Max Liquid Caplets
- Caffeine Free Beverage Package
- Ignition Stix (Ignition Stix)
- Beverage Package Max
- Liquid Funds
- Hardcore (Ready-to-Drink) RTDs
- Max Aqua Shed
- 24
- Boat Authority
- Environment
- Regular Beverage Package
Iovate marketed products to help with weight loss, promote hydration, and increase energy and fat burning. Some of the products are aimed at bodybuilders looking to lose fat to make their muscles look “trimmed,” in other words, they’re well-defined.
The inclusion of Hydroxycitric Acid in the product is a story of bad science and bad laws that have tied the hands of drug safety regulators.
Hydroxycitric acid is a type of citric acid that contains Garcinia gummi-gutta, a yellow, pumpkin-like fruit from Indonesia. The extract and bark are used in traditional Indian medicine and as a spice. Previous studies with mice have shown that Hydroxycitric Acid has an amazing ability to stop the conversion of carbohydrates to fat and also suppress appetite.
If it works for mice, it must work for humans, so supplement manufacturers add it to their products. They failed to take the critical steps required by the FDA for pharmaceuticals, clinical trials to demonstrate safety and effectiveness in humans.
Other researchers did their homework. A report in the Journal of the American Medical Association in 1998, when tested against a placebo, an inactive substance, HCA did not produce more severe disease than placebo. A 2000 study showed that HCA had no effect on reducing hunger or increasing satiety, the feeling of being full.
Work for a mouse. Not for humans. HCA supplement manufacturers left their products and did not change their claims.
In 2005 the Journal of Internal Medicine There have been two cases of liver damage from the use of Hydroxycut products containing HCA. Since then, numerous reports have continued to appear in the medical literature linking dietary supplements containing Hydroxycitric Acid to liver damage.
It is safe for mice. It is bad for people. Manufacturers left supplements in their products and did not change their claims.
The FDA’s hands were tied. Since the passage of the Hatch-Harkin Act in 1994, their involvement in dietary supplements, a $24 billion dollar business in the US, has had no FDA control over supplements coming to the market. He can’t review what people have to test for safety and efficacy—that’s what the agency does with all prescription drugs. The agency can only inspect the manufacturers and monitor the products once they are on the shelves.
They followed the reports and in May they did what was allowed by law. They published reports of 23 cases of liver damage, including one death. They sent a “doctor friendly” letter to health care providers across the country, saying that Hydroxycut products are a public health hazard.
The FDA has solid science and facts on its side. Iovate took their product off the market.
People who have used Hydroxycut products and experience symptoms they believe may be related to its use should contact their healthcare provider immediately.
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