Symptoms Associated With Excessive Weight Loss Due To Anorexia Nervosa What is Large Cell Lymphoma?

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What is Large Cell Lymphoma?

Lymphoma is a malignant disease found in the lymph system, especially in the lymphocytes. The most common cells that show malignancy in lymphoma are B-cells or B-lymphocytes and T-cells or T-lymphocytes. These lymphocytes are responsible for destroying pathogens that enter the body and remember to destroy them faster when they attack the system. Lymphoma is divided into Hodgkin’s Lymphoma (formerly known as Hodgkin’s Disease) and Non-Hodgkin’s Lymphoma. The main difference between the two is the presence of Reed-Sternberg cells, which are found in Hodgkin’s lymphoma.

Large cell lymphoma is a type of lymphoma classified under Non-Hodgkin lymphoma. This type of aggressive lymphoma affects B-lymphocytes more than T-lymphocytes. Large cell lymphoma is named because this type has more malignant cells compared to malignant cells in other types of lymphoma. Because of its similarity to Burkitt’s lymphoma, careful morphological and clinical studies are necessary to avoid the wrong type of treatment.

The cause of this disease is unknown. However, viral infections such as HIV/AIDS and the Epstein-Barr virus are known risk factors for developing this condition. Exposure to radiation during cancer treatment can increase the risk of developing secondary lymphoma.

Signs and symptoms of large cell lymphoma include:

– Swollen, painless lymph nodes

– Fatigue due to anemia

– Immortality

– Night sweats

– Unexplained weight loss

– Unexplained fever

After reviewing the medical history and physical examination, a lymph node biopsy is performed to confirm the diagnosis of large cell lymphoma. This is done by taking a tissue sample through minimally invasive surgery and studying it under a microscope. Once the diagnosis is confirmed, several laboratory tests such as imaging studies (X-Rays, PET Scan, CT-Scan, Ultrasound) and blood tests are performed to determine the disease.

Treatment of large cell lymphoma depends on the stage. A combination of immunotherapy and chemotherapy is the standard of care for lymphoma. Drugs include Rituxan, cytoxan, oncovin, and prednisone, a combination of immunotherapy, chemotherapy, and steroids. This is done in an aggressive stage of large cell lymphoma. Once the disease enters its stage, ICE or DHAP is used. Stage I and Stage II are treated with local radiation therapy, although radiation therapy may also be used along with chemotherapy when large cell lymphoma is present at a later stage. A bone marrow transplant is usually done as an aggressive treatment as a last-ditch attempt to beat the disease. Research is still being done in order to fully understand the cause of large cell lymphoma so that it can be treated properly and without too much stress on the body caused by the negative effects of the medicine.

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